Columbia scientists discover surprising link between serotonin and heart valve disease

Columbia scientists have found a surprising connection between serotonin and heart valve disease, suggesting that the chemical may accelerate the progression of degenerative mitral regurgitation in certain individuals. Research indicates that patients with this condition who take SSRI antidepressants and have a specific genetic variant may experience severe valve damage earlier in life. This discovery may lead to earlier surgical interventions for affected patients, potentially at a younger age. The findings highlight a previously unknown link between serotonin and heart health.

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